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2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A

Cyclosporine Derivative

2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A is a cyclosporine derivative that targets cytokine production through inhibition of T cell activation. This compound demonstrates significant biological activity, exhibiting an IC50 of 0.11 μg/mL in mixed lymphocyte reactions. It is primarily utilized in immunological research to investigate T cell responses and explore potential therapeutic applications in autoimmune diseases and organ transplantation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	164028-89-1
Applications	Cyclosporine Derivative
Formula	C₆₄H₁₁₄N₁₄O₁₃
Molecular Weight	1287.68
SMILES	C/C=C/C[C@@H](C)[C@H]([C@]1([H])N(C([C@@H](N(C([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)COCCN=[N+]=[N-])=O)C)CC(C)C)=O)C)CC(C)C)=O)C)C(C)C)=O)C)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.