Fig. 1 · Structure
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2'-O,4'-C-Methyleneguanosine
Nucleotide
2'-O,4'-C-Methyleneguanosine is a locked nucleic acid (LNA) analog of guanine that enhances nucleotide stability and binding affinity. This unique modification shows superior nuclease resistance compared to natural nucleotides, making it ideal for applications in disease diagnosis and molecular research. As a substrate for KOD DNA polymerase, 2'-O,4'-C-Methyleneguanosine allows for efficient incorporation into DNA strands, facilitating the synthesis of full-length extension products.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 207131-16-6 |
| Applications | Nucleotide |
| Formula | C11H13N5O5 |
| Molecular Weight | 295.25 |
| Synonyms | LNA-G |
| SMILES | OC[C@]12[C@@H](O)[C@@H](OC2)[C@H](N3C(N=C(N)NC4=O)=C4N=C3)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.