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2'-Ome-Ac-G Phosporamidite

Nucleoside

2'-Ome-Ac-G Phosphoramidite is a modified nucleoside that features a 2'-O-methyl and acetyl group on the guanosine moiety. This compound serves as a crucial building block for synthesizing oligonucleotides, offering enhanced stability and improved binding affinity in various molecular biology applications. It is particularly useful in the development of antisense oligonucleotides and RNA therapeutics, facilitating research in gene regulation and target-specific RNA interactions.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	909033-40-5
Applications	Nucleoside
Formula	C₄₃H₅₂N₇O₉P
Molecular Weight	841.89
Synonyms	5'-DMT-2'-OMe-rG(N-Ac) Phosphoramidite
SMILES	CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H](OC)[C@H](N(C=N2)C3=C2C(N=C(NC(C)=O)N3)=O)O[C@@H]1COC(C4=CC=C(OC)C=C4)(C5=CC=CC=C5)C6=CC=C(OC)C=C6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.