Fig. 1 · Structure
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2-PMPA sodium
GCPII Inhibitor
2-PMPA sodium is a potent inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 0.0003 μM. This compound effectively blocks the hydrolysis of N-acetylaspartylglutamate (NAAG), thereby modulating glutamate levels within the brain and influencing neurovascular coupling. Due to its specific action on GCPII, 2-PMPA sodium is valuable for investigating neurological diseases and understanding their underlying mechanisms. However, it is noted for its limited permeability across the blood-brain barrier, which may inform experimental design in related research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 373645-42-2 |
| Applications | GCPII Inhibitor |
| Formula | C6H7Na4O7P |
| Molecular Weight | 314.05 |
| Synonyms | 2-(Phosphonomethyl)pentanedioic acid sodium |
| SMILES | O=C(O[Na])C(CP(O[Na])(O[Na])=O)CCC(O[Na])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.