Fig. 1 · Structure
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2′-Thioadenosine
ErbB-1/2 Inhibitor
2′-Thioadenosine is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, demonstrating an IC50 of 45 µM for ErbB-2. Its primary mechanism involves the covalent modification of a cysteine residue at the active site of ErbB-1, leading to inactivation of the receptor. This compound is primarily employed in research applications focusing on cancer biology and targeted therapies where ErbB signaling pathways play a crucial role.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 136904-69-3 |
| Applications | ErbB-1/2 Inhibitor |
| Formula | C10H13N5O3S |
| Molecular Weight | 283.31 |
| Synonyms | PD157432 |
| SMILES | NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3S)C2=NC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.