Fig. 1 · Structure
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22(R)-Hydroxycholesterol
LXR Agonist
22(R)-Hydroxycholesterol is an endogenous liver X receptor (LXR) agonist that plays a crucial role in lipid metabolism and cholesterol homeostasis. This compound has been shown to activate LXR, leading to the regulation of genes involved in lipid biosynthesis and inflammation. It is particularly relevant in the research of Tangier disease and other metabolic disorders related to cholesterol transport and homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 17954-98-2 |
| Applications | LXR Agonist |
| Formula | C27H46O2 |
| Molecular Weight | 402.65 |
| Synonyms | Narthesterol |
| SMILES | O[C@@H](CC[C@@]12C)CC1=CC[C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@]4([H])[C@H](C)[C@@H](CCC(C)C)O)[H])C)[H])[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.