Fig. 1 · Structure
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22-SLF
PROTAC Degrader for FKBP12
22-SLF is a PROTAC degrader specifically targeting FK506-binding protein 12 (FKBP12), exhibiting a DC50 of 0.5 µM. This compound forms a ternary complex with C227 and C228 in FBXO22, facilitating FKBP12 degradation in an FBXO22-dependent manner. 22-SLF is a valuable tool for cancer research, serving as a probe to investigate the FBXO22-mediated degradation pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3079209-82-5 |
| Applications | PROTAC Degrader for FKBP12 |
| Formula | C60H76ClN5O13S |
| Molecular Weight | 1142.79 |
| SMILES | CCC(C)(C(C(N1CCCC[C@H]1C(O[C@@H](C2=CC(OCC(NCCCOCCOCCOCCCN(C(C3=NC4=C(S3)C=CC=C4)C(NCC5=CC=CC=C5)=O)C(CCl)=O)=O)=CC=C2)CCC6=CC=C(C(OC)=C6)OC)=O)=O)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.