Fig. 1 · Structure
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(2R,6R)-Hydroxynorketamine hydrochloride
Active Ketamine Metabolite
(2R,6R)-Hydroxynorketamine hydrochloride is an active metabolite of ketamine that does not exhibit NMDA receptor binding activity. This compound has been shown to enhance impaired long-term potentiation in the dorsal hippocampus and successfully restore significant long-term potentiation in the hippocampal SC-CA1 pathway. It is a valuable reagent for research focused on the mechanisms underlying depression and neuroplasticity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1430202-69-9 |
| Applications | Active Ketamine Metabolite |
| Formula | C12H15Cl2NO2 |
| Molecular Weight | 276.16 |
| Synonyms | (2R,6R)-HNK (hydrochloride) |
| SMILES | N[C@@]1(C([C@@H](CCC1)O)=O)C2=C(C=CC=C2)Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.