Fig. 1 · Structure
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(2S,6S)-Hydroxynorketamine hydrochloride
α7-nAChR Antagonist
(2S,6S)-Hydroxynorketamine hydrochloride is an antagonist of the α7-nicotinic acetylcholine receptor (nAChR). It exhibits potential neurorelaxant, antidepressant, and analgesic effects, facilitating the activation of the mTOR pathway and promoting increased phosphorylation of downstream targets. This compound is of particular interest in neurological research, particularly in the exploration of therapeutic avenues for mood disorders and pain management.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1430202-70-2 |
| Applications | α7-nAChR Antagonist |
| Formula | C12H15Cl2NO2 |
| Molecular Weight | 276.16 |
| Synonyms | (2S,6S)-HNK hydrochloride |
| SMILES | N[C@]1(C([C@H](CCC1)O)=O)C2=C(C=CC=C2)Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.