3-(1-Carboxyvinyloxy)benzoic acid is a potent inhibitor of MbtI, the salicylate synthase enzyme in Mycobacterium tuberculosis, and also inhibits arginine synthase (AS) in Serratia marcescens, exhibiting Ki values of 500 µM and 3.2 µM, respectively. This compound demonstrates significant antibacterial activity, making it a valuable reagent for anti-infection research and the development of novel therapeutic strategies against bacterial pathogens. Its selective inhibition of key enzymes highlights its potential utility in exploring the metabolic pathways of bacterial infections.
3-(1-Carboxyvinyloxy)benzoic acid is a potent inhibitor of MbtI, the salicylate synthase enzyme in Mycobacterium tuberculosis, and also inhibits arginine synthase (AS) in Serratia marcescens, exhibiting Ki values of 500 µM and 3.2 µM, respectively. This compound demonstrates significant antibacterial activity, making it a valuable reagent for anti-infection research and the development of novel therapeutic strategies against bacterial pathogens. Its selective inhibition of key enzymes highlights its potential utility in exploring the metabolic pathways of bacterial infections.
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