Fig. 1 · Structure
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3-(1-Carboxyvinyloxy)benzoic acid
MbtI Inhibitor
3-(1-Carboxyvinyloxy)benzoic acid is a potent inhibitor of MbtI, the salicylate synthase enzyme in Mycobacterium tuberculosis, and also inhibits arginine synthase (AS) in Serratia marcescens, exhibiting Ki values of 500 µM and 3.2 µM, respectively. This compound demonstrates significant antibacterial activity, making it a valuable reagent for anti-infection research and the development of novel therapeutic strategies against bacterial pathogens. Its selective inhibition of key enzymes highlights its potential utility in exploring the metabolic pathways of bacterial infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 16929-37-6 |
| Applications | MbtI Inhibitor |
| Formula | C10H8O5 |
| Molecular Weight | 208.17 |
| SMILES | O=C(C(OC1=CC=CC(C(O)=O)=C1)=C)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.