3,3'-Difluorobenzaldazine is a selective positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It enhances the efficacy of mGlu5 agonists, including glutamate, quisqualate, and 3,5-dihydroxyphenylglycine, increasing their action by 3- to 6-fold with effective concentrations (EC50) ranging from 2 to 5 μM. This compound is valuable for research applications focused on modulation of glutamatergic signaling and the investigation of neurological disorders associated with mGluR5 dysfunction.
3,3'-Difluorobenzaldazine is a selective positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It enhances the efficacy of mGlu5 agonists, including glutamate, quisqualate, and 3,5-dihydroxyphenylglycine, increasing their action by 3- to 6-fold with effective concentrations (EC50) ranging from 2 to 5 μM. This compound is valuable for research applications focused on modulation of glutamatergic signaling and the investigation of neurological disorders associated with mGluR5 dysfunction.
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