Fig. 1 · Structure
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3,3'-Difluorobenzaldazine
mGluR5 Positive Allosteric Modulator
3,3'-Difluorobenzaldazine is a selective positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It enhances the efficacy of mGlu5 agonists, including glutamate, quisqualate, and 3,5-dihydroxyphenylglycine, increasing their action by 3- to 6-fold with effective concentrations (EC50) ranging from 2 to 5 μM. This compound is valuable for research applications focused on modulation of glutamatergic signaling and the investigation of neurological disorders associated with mGluR5 dysfunction.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 15332-10-2 |
| Applications | mGluR5 Positive Allosteric Modulator |
| Formula | C14H10F2N2 |
| Molecular Weight | 244.24 |
| Synonyms | DFB |
| SMILES | FC1=CC(/C=N/N=C/C2=CC=CC(F)=C2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.