Fig. 1 · Structure
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3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione
Ligands for E3 Ligase
3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione is an effective ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is instrumental in studies focused on ubiquitin-mediated proteolysis and can be utilized in various research applications aimed at elucidating protein function and regulation. Its unique structural features enable specific binding interactions that are crucial for the development of innovative therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2924092-66-8 |
| Applications | Ligands for E3 Ligase |
| Formula | C11H9BrFNO2 |
| Molecular Weight | 286.10 |
| SMILES | O=C1NC(=O)C(C2=CC=C(Br)C=C2F)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.