Fig. 1 · Structure
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3,4-Dephostatin
PTPase
3,4-Dephostatin is a selective inhibitor of protein-tyrosine phosphatase (PTPase), pivotal for regulating tyrosine phosphorylation in cellular signaling. This reagent has been shown to enhance nerve growth factor (NGF)-induced neurite formation in PC12h cells, facilitating neuronal differentiation. Additionally, 3,4-Dephostatin prolongs the tyrosine phosphorylation and activation of mitogen-activated protein (MAP) kinase in response to both NGF and epidermal growth factor (EGF), making it a valuable tool for studies on signaling pathways and cellular growth responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 173043-84-0 |
| Applications | PTPase |
| Formula | C7H8N2O3 |
| Molecular Weight | 168.15 |
| Synonyms | Methyl-3,4-dephostatin |
| SMILES | OC1=CC=C(N(C)N=O)C=C1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.