Fig. 1 · Structure
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3,4-Dichloroisocoumarin
Serine-protease Inhibitor
3,4-Dichloroisocoumarin is a selective inhibitor of serine proteases, functioning through acylation of the enzyme after being activated by proteases themselves, with a Ki value for SrLip of 26.6 μM. This compound is known to induce DNA fragmentation and apoptosis, making it valuable in apoptosis research. It is applicable in studies related to tumor biology, cardiovascular disease mechanisms, and the functional analysis of enzyme catalysis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 51050-59-0 |
| Applications | Serine-protease Inhibitor |
| Formula | C9H4Cl2O2 |
| Molecular Weight | 215.03 |
| SMILES | ClC1=C(OC(C2=C1C=CC=C2)=O)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.