Fig. 1 · Structure
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3-AP-Me
3-AP Derivatives
3-AP-Me is a dimethyl derivative of 3-aminophenyl (3-AP) that acts as an inhibitor of ribonucleotide reductase. This compound activates the endoplasmic reticulum (ER) stress pathway by facilitating the phosphorylation of eIF2α and enhancing the expression of ATF4 and ATF6 transcription factors, ultimately promoting apoptosis in cells. Furthermore, 3-AP-Me activates stress kinases, including c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases, and induces the upregulation of the spliced mRNA variant XBP1, making it a valuable tool in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1184391-57-8 |
| Applications | 3-AP Derivatives |
| Formula | C9H13N5S |
| Molecular Weight | 223.30 |
| SMILES | NC1=CC=CN=C1/C=N/NC(N(C)C)=S |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.