Fig. 1 · Structure
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3-Bromocytisine
nAChR Agonist
3-Bromocytisine is a potent agonist of nicotinic acetylcholine receptors (nAChRs), exhibiting IC50 values of 0.28 nM, 0.30 nM, and 31.6 nM for human α4β4, α4β2, and α7 nAChRs, respectively. It demonstrates differential effects on high sensitivity (HS) and low sensitivity (LS) α4β2 nAChRs, with EC50 values of 8 nM and 50 nM, respectively. This compound is valuable for research in neuropharmacology and studies related to nicotine addiction and receptor pharmacodynamics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 207390-14-5 |
| Applications | nAChR Agonist |
| Formula | C11H13BrN2O |
| Molecular Weight | 269.14 |
| Synonyms | 3-Br-cytisine |
| SMILES | O=C1N2C([C@]3([H])C[C@](CNC3)([H])C2)=CC=C1Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.