Fig. 1 · Structure
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3-Chlorodiphenylamine
Ca2+ Sensitizer
3-Chlorodiphenylamine is a potent Ca2+ sensitizer primarily targeting cardiac muscle. It exhibits high affinity for the isolated N-domain of cardiac troponin C (cTnC), with a dissociation constant (Kd) of 6 µM. This compound serves as a valuable scaffold for the development of more effective Ca2+-sensitizing agents and is applicable in research focused on systolic heart failure.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 101-17-7 |
| Applications | Ca2+ Sensitizer |
| Formula | C12H10ClN |
| Molecular Weight | 203.67 |
| SMILES | ClC1=CC(NC2=CC=CC=C2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.