Target & Activity
| Target | Activity | Value |
|---|---|---|
| S-adenosylhomocysteine hydrolase () | Ki | 50 pM |
Fig. 1 · Structure
Documents & Downloads
3-deazaneplanocin A HCl (DZNep HCl)
Cat. No.
A13947
CAS
120964-45-6
EZH2 inhibitor
3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 120964-45-6 |
| Applications | EZH2 inhibitor |
| Formula | C12H15ClN4O3 |
| Molecular Weight | 298.73 |
| Synonyms | DZNep; NSC 617989 |
| SMILES | C1=CN=C(C2=C1N(C=N2)[C@@H]3C=C([C@H]([C@H]3O)O)CO)N.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 49 mg/mL (164.03 mM) |
| Water | 49 mg/mL (164.03 mM) |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 28 mg/mL
- Vehicle
- Saline
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.