3-deazaneplanocin A HCl (DZNep HCl)

Catalog No.: A13947

EZH2 inhibitor

3-deazaneplanocin A HCl (DZNep HCl) Chemical Structure

CAS NO. 120964-45-6

3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma.

Availability: In stock

Package Price Qty
2 mg

Regular Price: $150.00

Special Price $120.00

5 mg

Regular Price: $300.00

Special Price $240.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma.
Targets
S-adenosylhomocysteine hydrolase ()
50 pM(Ki)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.48 mL 167.38 mL 334.75 mL
0.5 mM 6.7 mL 33.48 mL 66.95 mL
1 mM 3.35 mL 16.74 mL 33.48 mL
5 mM 0.67 mL 3.35 mL 6.7 mL

*The above data is based on the productmolecular weight 298.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13947
Actions Inhibitor
M. Wt 298.73
Formula C12H15ClN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 120964-45-6
Synonyms DZNep, NSC 617989
SMILES C1=CN=C(C2=C1N(C=N2)[[email protected]@H]3C=C([[email protected]]([[email protected]]3O)O)CO)N.Cl

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