3-deazaneplanocin A HCl (DZNep HCl)

Catalog No.: A13947

EZH2 inhibitor

3-deazaneplanocin A HCl (DZNep HCl)

3-deazaneplanocin A HCl (DZNep HCl) Chemical Structure

CAS NO. 120964-45-6

3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma.

Availability: In stock

Package Price Qty
2 mg
$150.00
5 mg
$300.00
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Biological Activity

3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma.
Targets
S-adenosylhomocysteine hydrolase ()
50 pM(Ki)
In vitro (25°C) DMSO 49 mg/mL (164.03 mM)
Water 49 mg/mL (164.03 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.48 mL 167.38 mL 334.75 mL
0.5 mM 6.7 mL 33.48 mL 66.95 mL
1 mM 3.35 mL 16.74 mL 33.48 mL
5 mM 0.67 mL 3.35 mL 6.7 mL

*The above data is based on the productmolecular weight 298.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13947
Actions Inhibitor
CAS No. 120964-45-6
Formula C12H15ClN4O3
M. Wt 298.73
Solubility DMSO
Purity >98%
Synonyms DZNep, NSC 617989
SMILES C1=CN=C(C2=C1N(C=N2)[[email protected]@H]3C=C([[email protected]]([[email protected]]3O)O)CO)N.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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