Fig. 1 · Structure
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3'-Fluoroaminopterin
Drug Derivative
3'-Fluoroaminopterin is a derivative of aminopterin, primarily targeting dihydrofolate reductase. It exhibits potent antitumor activity by inhibiting folate metabolism, thereby interfering with DNA synthesis and cell proliferation. This compound is utilized in cancer research and studies involving folate pathway modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 85803-34-5 |
| Applications | Drug Derivative |
| Formula | C19H19FN8O5 |
| Molecular Weight | 458.40 |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(N)N=C(N)N=C3N=C2)C(F)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.