Fig. 1 · Structure
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3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles
BMP2 Inhibitor
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles functions as a selective inhibitor of bone morphogenetic protein 2 (BMP2), exhibiting an IC50 value of 2.2 μM. This compound also inhibits mitogen-activated protein kinase 1 (MEK1), suggesting its potential in signaling pathway modulation. Additionally, it demonstrates anti-inflammatory and neuroprotective effects in the experimental autoimmune encephalomyelitis (EAE) mouse model, supporting its applications in studies related to neuroinflammatory conditions and BMP2-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 287196-91-2 |
| Applications | BMP2 Inhibitor |
| Formula | C11H6F3N3OS |
| Molecular Weight | 285.25 |
| SMILES | N#CC1=C(NC2=CC=CC=C2C(F)(F)F)SNC1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.