Fig. 1 · Structure
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3-Hydroxy agomelatine-d3
5-HT2C Receptor Antagonist
3-Hydroxy agomelatine-d3 is a deuterium-labeled analog of 3-Hydroxy agomelatine, acting as a selective antagonist of the 5-HT2C receptor. This compound demonstrates an IC50 value of 3.2 μM and a Ki of 1.8 μM, indicating its capacity to effectively inhibit receptor activity. It is valuable in research applications focused on neuropharmacology, particularly in studying mood disorders and the modulation of serotonergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1079774-23-4 |
| Applications | 5-HT2C Receptor Antagonist |
| Formula | C15H14D3NO3 |
| Molecular Weight | 262.32 |
| SMILES | CC(NCCC1=C2C=C(OC([2H])([2H])[2H])C=CC2=CC(O)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.