Fig. 1 · Structure
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3-Methylthiophene-2-carboxylic acid
PqsE Inhibitor
3-Methylthiophene-2-carboxylic acid is a potent inhibitor of the Pseudomonas quinolone signal system protein E (PqsE), exhibiting a Kd of 19.6 µM and an IC50 of 40 µM. This compound binds to the active site of PqsE, leading to inhibition of thioesterase activity. Additionally, it effectively permeates Pseudomonas aeruginosa, influencing 2,4-dihydroxyquinoline (DHQ) levels similarly to the deletion of the PqsE gene. Its ability to modulate PqsE activity makes it valuable for research into cystic fibrosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 23806-24-8 |
| Applications | PqsE Inhibitor |
| Formula | C6H6O2S |
| Molecular Weight | 142.18 |
| SMILES | CC(C=CS1)=C1C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.