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3'-O-(2-Nitrobenzyl)-dCTP

Reversible Terminator

3'-O-(2-Nitrobenzyl)-dCTP is a reversible terminator that effectively halts primer extension during DNA synthesis. It is efficiently incorporated by DNA polymerases, which allows temporary interruption of the extension reaction. Following this incorporation, the 3'-O-(2-nitrobenzyl) blocking group can be cleaved using laser irradiation, regenerating a free 3'-OH group for subsequent extension cycles. This reagent is particularly useful for addressing challenges associated with homopolymeric regions in DNA templates.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	959755-19-2
Applications	Reversible Terminator
Formula	C₁₆H₂₁N₄O₁₅P₃
Molecular Weight	602.28
SMILES	OP(OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)C[C@@H]1OCC3=CC=CC=C3[N+]([O-])=O)(OP(OP(O)(O)=O)(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.