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3'-O-(2-Nitrobenzyl)-dGTP

Reversible Terminator

3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator that functions by temporarily halting DNA primer extension. It is efficiently recognized and incorporated by DNA polymerases, allowing for precise control during DNA synthesis. Upon removal of the 2-nitrobenzyl blocking group through laser irradiation, a free 3'-OH group is regenerated, facilitating subsequent polymerase-driven extension. This reagent is particularly useful in DNA sequencing applications, enabling enhanced accuracy and flexibility in studies of nucleic acid sequences.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	959755-49-8
Applications	Reversible Terminator
Formula	C₁₇H₂₁N₆O₁₅P₃
Molecular Weight	642.30
SMILES	OP(OC[C@H]1O[C@@H](N2C(NC(N)=NC3=O)=C3N=C2)C[C@@H]1OCC4=CC=CC=C4[N+]([O-])=O)(OP(OP(O)(O)=O)(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.