Fig. 1 · Structure
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3-Oxobetulin acetate
Antancer
3-Oxobetulin acetate, a derivative of betulin, serves as a cholesterol biosynthesis inhibitor. This compound demonstrates notable cytotoxic activity against P388 murine lymphocytic leukemia cells (EC50=0.12 μg/mL) as well as several human cancer cell lines, including MCF-7 breast cancer, SF-268 CNS cancer, H460 lung cancer, and KM20L2 colon cancer, exhibiting GI50 values of 8, 10.6, 5.2, and 12.7 μg/mL, respectively. However, it shows limited efficacy against BxPC-3 pancreatic cancer and DU145 prostate cancer cells (GI50s > 10 μg/mL). Additionally, 3-Oxobetulin acetate effectively inhibits the replication of X4-tropic recombinant HIV in MT-2 lymphoblastoid cells (IC50=13.4 μM) and demonstrates activity against Listeria donovani amastigotes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 136587-07-0 |
| Applications | Antancer |
| Formula | C32H50O3 |
| Molecular Weight | 482.74 |
| Synonyms | 28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin |
| SMILES | CC1(C)C(CC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C)=C)CC[C@@](COC(C)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.