Fig. 1 · Structure
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306-N16B
Lipid Nanoparticle
306-N16B is a selective lung-targeted lipid nanoparticle designed to bind and deliver mRNA to lung endothelial and immune cells via a protein corona formation governed by tail structure differences. This mechanism enhances the accumulation of loaded mRNA in the lungs, facilitating efficient transfection and gene expression in targeted cell types such as macrophages and endothelial cells. 306-N16B is applicable in gene therapy for hereditary lung disorders like pulmonary lymphangioleiomyomatosis (LAM) and offers potential for lung-specific mRNA vaccines and gene editing strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2803699-70-7 |
| Applications | Lipid Nanoparticle |
| Formula | C75H151N7O4S8 |
| Molecular Weight | 1471.57 |
| SMILES | O=C(CCN(CCCN(CCCN(CCC(NCCSSCCCCCCCCCCCC)=O)CCC(NCCSSCCCCCCCCCCCC)=O)C)CCC(NCCSSCCCCCCCCCCCC)=O)NCCSSCCCCCCCCCCCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.