Fig. 1 · Structure
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(3S,5S,6R)-Navtemadlin
Isomer
(3S,5S,6R)-Navtemadlin serves as an isomeric control for Navtemadlin, a potent and selective inhibitor of the p53-MDM2 interaction. With an IC50 value of 0.6 nM, Navtemadlin demonstrates high affinity for MDM2, as evidenced by its Kd of 0.045 nM. This reagent is valuable for research applications aimed at understanding the modulation of p53 pathways and exploring potential therapeutic strategies for cancers with disrupted p53 functions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2459946-14-4 |
| Applications | Isomer |
| Formula | C28H35Cl2NO5S |
| Molecular Weight | 568.55 |
| Synonyms | (3S,5S,6R)-AMG 232; (3S,5S,6R)-KRT-232 |
| SMILES | CC(C)S(C[C@@H](N1[C@@H](C2=CC=C(C=C2)Cl)[C@H](C3=CC(Cl)=CC=C3)C[C@](C)(C1=O)CC(O)=O)C(C)C)(=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.