Fig. 1 · Structure
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4,6-O-Ethylidene-α-D-glucose
GLUT1 Inhibitor
4,6-O-Ethylidene-α-D-glucose is a competitive inhibitor of glucose transporter 1 (GLUT1), specifically targeting the exofacial binding site. With a Ki of 12 mM for the transport of wild-type 2-deoxy-D-glucose, this glucose derivative can be utilized in research focused on glucose metabolism and transport mechanisms. Its inhibitory effects on GLUT1 make it valuable for studies related to glucose-dependent pathologies, including cancer and metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 13224-99-2 |
| Applications | GLUT1 Inhibitor |
| Formula | C8H14O6 |
| Molecular Weight | 206.19 |
| Synonyms | Ethylidene-glucose |
| SMILES | [H][C@]12[C@@](O[C@H](O)[C@H](O)[C@H]2O)([H])COC(C)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.