Fig. 1 · Structure
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4-Br-Bnlm
Grp94 Inhibitor
4-Br-Bnlm is a selective inhibitor of glucose-regulated protein 94 (Grp94), exhibiting an EC50 value of 0.96 µM. This compound effectively reduces the levels of both mutant and misfolded wild-type myocilin proteins in cellular contexts. By promoting the clearance of toxic forms of myocilin, 4-Br-Bnlm demonstrates significant potential for reducing myocilin-associated cytotoxicity, making it a valuable tool for research into glaucoma and related protein misfolding diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1654775-71-9 |
| Applications | Grp94 Inhibitor |
| Formula | C20H18BrClN2O4 |
| Molecular Weight | 465.72 |
| SMILES | O=C(OC)C1=C(O)C=C(O)C(Cl)=C1CCC2=NC=CN2CC3=CC=C(Br)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.