Fig. 1 · Structure
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4-Bromo-3-hydroxybenzoic acid
Histidine Decarboxylase Inhibitor
4-Bromo-3-hydroxybenzoic acid is a selective inhibitor of histidine decarboxylase (HDC), demonstrating IC50 values of 1 mM for both rat fetal and rat gastric HDC isoforms. This compound also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro, with similar IC50s of 1 mM for both enzymes. Due to its inhibitory properties, 4-Bromo-3-hydroxybenzoic acid is useful in studying biochemical pathways involving histamine production and neurochemical modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 14348-38-0 |
| Applications | Histidine Decarboxylase Inhibitor |
| Formula | C7H5BrO3 |
| Molecular Weight | 217.02 |
| SMILES | O=C(O)C1=CC=C(Br)C(O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.