Fig. 1 · Structure
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4-Chlorokynurenine
Antidepressant/Neuroprotective Agent
4-Chlorokynurenine is a prodrug of 7-Chlorokynurenic acid, acting primarily as an NMDA receptor antagonist. This compound possesses oral bioavailability and penetrates the blood-brain barrier, making it effective for neuroprotection. It demonstrates significant antidepressant properties and reduces neurotoxicity, positioning it as a valuable tool in research focused on neurological disorders, including depression and seizures.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 153152-32-0 |
| Applications | Antidepressant/Neuroprotective Agent |
| Formula | C10H11ClN2O3 |
| Molecular Weight | 242.66 |
| Synonyms | 4-Cl-KYN; AV-101 |
| SMILES | OC([C@@H](N)CC(C1=C(C=C(C=C1)Cl)N)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.