Fig. 1 · Structure
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4-DAMP
M3/M5 Receptor Antagonist
4-DAMP (4-DAMP methiodide) is a selective antagonist of the M3 and M5 muscarinic acetylcholine receptors. This compound demonstrates significant biological activity by enhancing apoptosis and reducing cell viability in gastric cancer cell lines such as MKN45 and BGC823 when used in conjunction with 5-Fluorouracil. Additionally, 4-DAMP exhibits anti-inflammatory properties by inhibiting lipopolysaccharide (LPS) and tobacco-induced pulmonary inflammation, while also decreasing mucin 5AC (MUC5AC) secretion. Its applications in cancer research and inflammatory response studies make it a valuable tool for understanding muscarinic receptor signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1952-15-4 |
| Applications | M3/M5 Receptor Antagonist |
| Formula | C21H26INO2 |
| Molecular Weight | 451.34 |
| Synonyms | 4-DAMP methiodide |
| SMILES | C[N+]1(C)CCC(OC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC1.[I-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.