Fig. 1 · Structure
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4’-Hydroxy Trazodone
OAT
4'-Hydroxy Trazodone is a metabolite of the antidepressant trazodone and functions primarily as an inhibitor of organic anion transporter 3 (OAT3), exhibiting a Ki value of 16.9 μM. This compound demonstrates selectivity for OAT3 over OAT1, with a Ki value greater than 200 μM for the latter. Due to its inhibitory properties, 4'-Hydroxy Trazodone can be utilized in research focused on transporter-mediated drug interactions and the pharmacokinetics of antidepressants.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 53818-10-3 |
| Applications | OAT |
| Formula | C₁₉H₂₂ClN₅O₂ |
| Molecular Weight | 387.86 |
| SMILES | ClC1=CC(N2CCN(CCCN3N=C(C=CC=C4)N4C3=O)CC2)=CC=C1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.