Fig. 1 · Structure
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4'-Hydroxytamoxifen (metabolite of Tamoxifen)
ER Modulator
4'-Hydroxytamoxifen is an effective estrogen receptor (ER) modulator derived from Tamoxifen. This compound exhibits a higher binding affinity for ER compared to its parent compound, leading to enhanced biological activity. 4'-Hydroxytamoxifen is known to induce a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells, making it a valuable reagent for cancer research and studies exploring ER-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 82413-23-8 |
| Applications | ER Modulator |
| Formula | C26H29NO2 |
| Molecular Weight | 387.51 |
| SMILES | CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.