Fig. 1 · Structure
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4-Nitrothalidomide
Thalidomide Analogue
4-Nitrothalidomide is a nitrosylated analogue of Thalidomide, functioning as a ligand for E3 ligases. It facilitates the ubiquitination of target proteins, leading to their degradation via the proteasomal pathway. This compound is valuable for studying protein turnover and the role of ubiquitin-mediated degradation in cellular processes, making it particularly relevant for cancer and developmental biology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 19171-18-7 |
| Applications | Thalidomide Analogue |
| Formula | C13H9N3O6 |
| Molecular Weight | 303.23 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3[N+]([O-])=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.