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4-O-Methyl-ascochlorin

Anticancer Agent

4-O-Methyl-ascochlorin is an anticancer agent that selectively induces apoptosis in K562 leukemia cells. This compound facilitates G1 phase cell cycle arrest and downregulates c-Myc expression, impacting critical pathways in cell proliferation. Additionally, 4-O-Methyl-ascochlorin promotes the phosphorylation of AMPK while inhibiting mTOR activity and its downstream targets including p70S6K and 4E-BP-1. This reagent is valuable for research applications focused on leukemia and related malignancies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	38561-40-9
Applications	Anticancer Agent
Formula	C₂₄H₃₁ClO₄
Molecular Weight	418.95
SMILES	C[C@]1([C@H](C(CC[C@H]1C)=O)C)/C=C/C(C)=C/CC2=C(C(Cl)=C(C(C=O)=C2O)C)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.