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4-Sulfocalix4arene

Amyloid-beta 42 Binder

4-Sulfocalix[4]arene is an amyloid-beta 42 binder that exhibits a dissociation constant (Kd) of 5.39 µM, indicating a strong affinity for binding to this protein. Its ability to inhibit amyloid β-peptide fibrillation makes it a valuable tool in research focused on Alzheimer's disease pathology. Additionally, 4-Sulfocalix[4]arene can reduce the cytotoxicity associated with amyloid aggregates, providing insights for therapeutic strategies targeting amyloid-related neurodegeneration.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	112269-92-8
Applications	Amyloid-beta 42 Binder
Formula	C₂₈H₂₄O₁₆S₄
Molecular Weight	744.74
Synonyms	para-Sulfonatocalix[n]arene
SMILES	O=S(O)(C1=CC(CC2=CC(S(=O)(O)=O)=CC(CC3=C(O)C(CC4=C(O)C(C5)=CC(S(=O)(O)=O)=C4)=CC(S(=O)(O)=O)=C3)=C2O)=C(O)C5=C1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.