Fig. 1 · Structure
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(4R,5S)-YX-02-030
YX-02-030 Isomer
(4R,5S)-YX-02-030 is a stereoisomer of YX-02-030, functioning as a PROTAC (Proteolysis Targeting Chimera) designed to promote the degradation of MDM2. This compound exhibits potent biological activity in disrupting MDM2-mediated degradation of p53, thereby enhancing p53 activity and providing insights into cancer therapy. Its application is particularly relevant in studies of tumor suppression and cellular signaling pathways involving MDM2 and p53 interactions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3049077-01-9 |
| Applications | YX-02-030 Isomer |
| Formula | C66H85Cl2N9O10S |
| Molecular Weight | 1267.41 |
| SMILES | O=C(CN1CCN(C(N2[C@@](C)(C3=CC=C(Cl)C=C3)[C@@](C)(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC)=O)CC1)NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](O)C6)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.