Fig. 1 · Structure
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5,10-Dideazaaminopterin
L1210 Leukemia Against Agent
5,10-Dideazaaminopterin is a potent inhibitor of the enzyme dihydrofolate reductase (DHFR), targeting L1210 leukemia cells. It exhibits significant cytotoxic activity with an IC50 value of 17 nM, making it a valuable tool for cancer research. This compound is particularly useful in studies focusing on mechanisms of action against leukemia and therapeutic applications in hematological malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 95674-53-6 |
| Applications | L1210 Leukemia Against Agent |
| Formula | C21H22N6O5 |
| Molecular Weight | 438.44 |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CCC2=CC3=C(N)N=C(N)N=C3N=C2)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.