Fig. 1 · Structure
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5,10-Dideazafolic acid
GARFT Inhibitor
5,10-Dideazafolic acid is a potent inhibitor targeting glycine amide ribonucleotide formyltransferase (GARFT), with an affinity characterized by a Ki value of 13 μM. This compound demonstrates significant inhibitory activity, making it a valuable tool for studying purine biosynthesis and related metabolic pathways. Its application extends to research on cancer metabolism and the development of potential therapeutic strategies targeting GARFT.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 85597-18-8 |
| Applications | GARFT Inhibitor |
| Formula | C21H21N5O6 |
| Molecular Weight | 439.42 |
| SMILES | O=C(CC[C@H](NC(C1=CC=C(C=C1)CCC2=CN=C(NC(N)=NC3=O)C3=C2)=O)C(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.