Fig. 1 · Structure
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5-(2-Chloroacetamide) thalidomide
Thalidomide Analog
5-(2-Chloroacetamide) thalidomide is a Thalidomide analog that functions as an E3 ligase recruiter, facilitating the ubiquitination and targeted degradation of specific proteins. The inclusion of a chloroacetamide moiety enhances its reactivity towards thiol groups, potentially increasing its efficacy in modulating protein degradation pathways. This compound is of interest for research applications in targeted protein therapy and cancer biology, providing insights into the mechanisms of protein homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1957235-51-6 |
| Applications | Thalidomide Analog |
| Formula | C15H12ClN3O5 |
| Molecular Weight | 349.73 |
| SMILES | ClCC(NC1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.