Fig. 1 · Structure
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[5-(2-Thienyl)-3-isoxazolyl]methanol
AgrA-DNA Binding Inhibitor
5-(2-Thienyl)-3-isoxazolylmethanol is identified as an AgrA-DNA binding inhibitor, targeting the regulatory protein AgrA in Staphylococcus aureus. This compound demonstrates significant biological activity by interfering with AgrA-mediated gene expression, thereby providing valuable insights in the study of S. aureus infections and quorum sensing mechanisms. Its application can aid researchers exploring new therapeutic strategies against antibiotic-resistant strains of this pathogen.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 194491-44-6 |
| Applications | AgrA-DNA Binding Inhibitor |
| Formula | C8H7NO2S |
| Molecular Weight | 181.21 |
| SMILES | OCC1=NOC(C2=CC=CS2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.