Fig. 1 · Structure
Documents & Downloads
5,6,7,8-Tetrahydro-8-deazahomofolic acid
DNA/RNA Synthesi
5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential inhibitor of thymidylate synthase (TS), with activity against other folate-related enzymes. This compound demonstrates mild growth inhibition in enterococci, lactic acid bacteria, and L1210 cells in vitro. Additionally, it exhibits weak inhibitory effects on thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase, highlighting its utility in studying DNA and RNA synthesis pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 111113-75-8 |
| Applications | DNA/RNA Synthesi |
| Formula | C21H26N6O6 |
| Molecular Weight | 458.47 |
| SMILES | O=C1C2=C(NC(N)=N1)CC[C@@H](N2)CCNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.