Fig. 1 · Structure
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(±)5,6-DHET lactone
Lactone
(±)5,6-DHET lactone is a lactonized derivative of 5,6-EET and 5,6-DiHET. It exhibits potent vasodilatory effects in isolated canine coronary arterioles, achieving 41% and 100% inhibition at concentrations of 0.01 and 100 pM, respectively. Additionally, this compound induces vasodilation in isolated human microvessels and enhances intracellular calcium levels in a dose-dependent manner, an effect that can be inhibited by the nitric oxide scavenger L-NAME. This compound is valuable for research in cardiovascular biology and cellular signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 213126-92-2 |
| Applications | Lactone |
| Formula | C20H32O3 |
| Molecular Weight | 320.47 |
| Synonyms | (±)5,6-DiHETrE lactone |
| SMILES | O=C1CCCC(C(O)C/C=C\C/C=C\C/C=C\CCCCC)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.