Fig. 1 · Structure
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5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone
ABCG2 Inhibitor
5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone is a flavonoid that functions as a potent inhibitor of the ABCG2 transporter, exhibiting an IC50 of 6.6 μM. This compound is significant for research in drug resistance mechanisms and the modulation of pharmacokinetics. Its ability to inhibit ABCG2 may provide insights into enhancing therapeutic efficacy by overcoming efflux-mediated drug resistance in cancer cells and other diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1268140-15-3 |
| Applications | ABCG2 Inhibitor |
| Formula | C21H22O6 |
| Molecular Weight | 370.40 |
| SMILES | O=C1C2=C(O)C=C(O)C(C/C=C(C)\C)=C2O[C@H](C3=CC(O)=C(C=C3)OC)C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.