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5-Benzyloxytryptamine

5-HT1D/1B Agonist

5-Benzyloxytryptamine is a selective partial agonist of the 5-hydroxytryptamine 1D/1B (5-HT1D/1B) receptors, exhibiting an IC50 of 40 nM for bovine caudate 5-HT1D, with significantly lower affinity for 5-HT2 receptors (IC50 > 470 nM). This compound effectively inhibits adenylate cyclase, leading to a decrease in neurotransmitter release and downregulation of cAMP signaling. 5-Benzyloxytryptamine is valuable for the study of neurotransmitter imbalance-related disorders, particularly in research related to migraines.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Partial Agonist
CAS Number	20776-45-8
Applications	5-HT1D/1B Agonist
Formula	C₁₇H₁₈N₂O
Molecular Weight	266.34
Synonyms	5-BT
SMILES	NCCC1=CNC2=CC=C(OCC3=CC=CC=C3)C=C12

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.