Fig. 1 · Structure

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5-Chloro-2'-deoxyuridine

thymine analog

5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
L5178Y IC50 16 μM In vitro growth inhibition of L5178Y-Parental murine leukemia cells by incorporation of [14C]Leu. [PMID: 11101356]
L5178Y IC50 33 μM In vitro growth inhibition of L5178Y-Parental murine leukemia cells by incorporation of [14C]-Thd. [PMID: 11101356]

Specifications

Manufacturer Adooq Bioscience
CAS Number 50-90-8
Applications thymine analog
Formula C9H11ClN2O5
Molecular Weight 262.65
Synonyms 5-Chlorodeoxyuridine; CldU
SMILES
OC[C@@H]1[C@H](C[C@H](N2C(NC(C(Cl)=C2)=O)=O)O1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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