Fig. 1 · Structure
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5-DACTHF
GAR-TFase/AICAR-TFase Inhibitor
5-DACTHF acts as an inhibitor of GAR-transferase and AICAR-transferase, key enzymes in the purine de novo biosynthesis pathway. With IC50 values of 3 μM and 94 μM for the respective targets, it demonstrates substantial inhibitory potency. This compound is primarily utilized in cancer research, highlighting its potential as an effective antitumor agent.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 118252-44-1 |
| Applications | GAR-TFase/AICAR-TFase Inhibitor |
| Formula | C19H24N6O6 |
| Molecular Weight | 432.43 |
| Synonyms | 543U76; 5,11-Methenyltetrahydrohomofolate |
| SMILES | OC(CC[C@@H](C(O)=O)NC(C(C=C1)=CC=C1NCCCC2=C(NC(N)=NC2=O)N)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.