Fig. 1 · Structure
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5'-Deoxy-5-fluorocytidine
Metabolite Of Capecitabine
5'-Deoxy-5-fluorocytidine is a cytidine analog and active metabolite of Capecitabine. In the liver, Capecitabine is hydrolyzed to produce 5'-deoxy-5-fluorocytidine, which is subsequently deaminated by cytidine deaminase to yield 5'-deoxy-5-fluorouridine. This compound is further converted to 5-fluorouracil by thymidine phosphorylase in tumor tissues, contributing to its anti-tumor activity. 5'-Deoxy-5-fluorocytidine is primarily utilized in research focused on solid tumors, including colorectal cancer, non-small cell lung cancer, and breast cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 66335-38-4 |
| Applications | Metabolite Of Capecitabine |
| Formula | C9H12FN3O4 |
| Molecular Weight | 245.21 |
| Synonyms | 5-Fluoro-5'-deoxycytidine |
| SMILES | O=C(N=C(N)C(F)=C1)N1[C@@H]2O[C@H](C)[C@@H](O)[C@H]2O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.