5-HT1A agonist 1

Catalog No.: A29846
5-HT1a Receptor Agonist
5-HT1A agonist 1 is a highly selective agonist for the 5-HT1A receptor, exhibiting an EC50 of 0.18 nM. This compound mimics serotonin binding, facilitating postsynaptic membrane hyperpolarization, which inhibits neuronal hyperexcitability and decreases the release of anxiety-related neurotransmitters. 5-HT1A agonist 1 is a valuable tool in research focused on neuropsychiatric disorders.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
Description5-HT1A agonist 1 is a highly selective agonist for the 5-HT1A receptor, exhibiting an EC50 of 0.18 nM. This compound mimics serotonin binding, facilitating postsynaptic membrane hyperpolarization, which inhibits neuronal hyperexcitability and decreases the release of anxiety-related neurotransmitters. 5-HT1A agonist 1 is a valuable tool in research focused on neuropsychiatric disorders.
Product Information
Catalog NumA29846
FormulaC22H27N5O2
Molecular Weight393.48
CAS Number2410053-15-3
SMILESCC1=C2C(CCN(CCN3CCC(C4=NOC5=C4C=CC=C5)CC3)C2=O)=NN1C
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